Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3932 | CA9491 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 60 |
| 2 | 3TC+ D4T+ RTV | 30 |
| 3 | 3TC+ DDI+ RTV+ SQV | 17 |
| 4 | 3TC+ AZT+ NVP | 43 |
| 5 | DDI+ D4T+ DLV+ NFV | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82AT, L90M | L10I, I15V, K20R, E35D, M36I, N37E, L63P, A71X |
| >CA9491| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKXIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LI, M184MV, L210LW, T215SY | K101E | A98G | K32KN, V35I, R83K, V106I, V118VI, D123E, I135T, E138A, T200A, E203K, Q207QE, H208HY, R211K, K223KE, T286A, A288S, E297K |
| >CA9140| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKKTQDFWEVQLGIPHPGGLEKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFSTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |