Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1450 | CA9438 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | DDI+ AZT | 9 |
| 3 | AZT | 27 |
| 4 | DDC+ AZT | 43 |
| 5 | DDI+ AZT | 8 |
| 6 | AZT+ 3TC | 23 |
| 7 | SQV+ AZT+ 3TC | 55 |
| 8 | NFV+ D4T+ 3TC | 23 |
| 9 | NFV+ 3TC+ D4T | 31 |
| 10 | None | 17 |
| 11 | NFV+ D4T+ 3TC | 10 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35I, V106I, K122E, I135T, F214L, I293V, E297T |
| >CA9438| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTTEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K14R, I15V, E35D, H69Q, V82I |
| >CA9839| codons 1-99 PQITLWQRPIVTIRVGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGQKAIGTVLVGPTPINIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |