Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4100 | CA9395 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 69 |
| 2 | DDI | 39 |
| 3 | 3TC+AZT | 57 |
| 4 | D4T+DDI+NVP | 104 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | V75VA, K219Q | Y181C | A98AG | K20R, I31IL, L34LI, V35A, T39A, V118VI, I135L, S162D, F214L, L228H, K281KR, E297P | T286AG |
| >CA9395| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKLKAIAEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLADFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTEVIPLTPEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, L63P |
| >CA9800| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |