Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA640 | CA9344 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 52 |
| 2 | 3TC+AZT+SQV | 61 |
| 3 | 3TC+AZT+IDV | 39 |
| 4 | 3TC+D4T+RTV+SQV | 22 |
| 5 | AZT+DDI+NVP+RTV+SQV | 49 |
| 6 | 3TC+AZT+EFV+RTV+SQV+Unknown | 34 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | Y188L, G190GA | D123E, I135T, I142T, D177E, V179I, G196E, L228R, D237DE, K275Q, T286A, A288G, I293V, P294T, E297K |
| >CA9344| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLLVASDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFRWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGAKGLTEVVTLTKE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V | K43T | L10I, G17E, N37D, L63P, C67S, A71V, I72V, V77I, I93L |
| >CA9521| codons 1-99 PQITLWQRPIVTIKIGEQLKEALLDTGADDTVLEEMDLPGRWTPKMIVGIGGFVKVRQYD QIPIEISGHKVVGTVLIGPTPANVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |