Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1415 | CA9241 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 83 |
| 2 | AZT+DDI | 30 |
| 3 | DDC | 91 |
| 4 | 3TC+AZT | 52 |
| 5 | 3TC+AZT+IDV | 83 |
| 6 | D4T+NFV+NVP | 26 |
| 7 | D4T+DDI+NFV+SQV | 42 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215Y | K219Q | K101E, K103KN, Y181C | K20R, V35T, T39A, K122E, K166R, Q207E, L228H |
| >CA9241| codons 1-262 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFYTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A | K43T | L10I, E34Q, L63P, A71V, Q92K |
| >CA9593| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWTPKMIGGIGGFAKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive value of HIV-1 genotypic resistance test interpretation algorithms. | J Infect Dis, 2009 |