Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3978 | CA9225 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 57 |
| 2 | 3TC+AZT | 22 |
| 3 | 3TC+AZT+IDV | 74 |
| 4 | DDI+NFV+NVP | 56 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, L210W, T215Y | K103N, Y181C | E28K, V35I, T39A, K43E, E44ED, V118I, K122KE, I135T, I142V, G196E, R211K, V245Q |
| >CA9225| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALIEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | F53L, G73S | L10I, I13IV, N37D, K55R, L63P, H69HR, A71V, I93L |
| >CA9552| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGLVRVRQYD QIPIEICGRKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |