Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2256 | CA9177 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 29 |
| 2 | AZT+DDC | 78 |
| 3 | 3TC+AZT+SQV | 8 |
| 4 | AZT | 17 |
| 5 | 3TC+AZT+RTV | 9 |
| 6 | 3TC+AZT | 51 |
| 7 | D4T+IDV | 16 |
| 8 | D4T+IDV+RTV | 47 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K11R, V35I, K43N, E44ED, R83K, G196E, T200A, Q207E, H208HY, R211K, L228HR, V245E, A272P, K277R, Q278H, T286A, E297R, G333E, R358RK, A360AT, A400L, E404N, N418S, L452A, D460N, H483Y, A554S |
| >CA9177| codons 1-560 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRAKIEELREYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMKGT HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWELWWTNYWQATWIPEWEFVSTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKAGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSSGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, I15V, K20M, M36I, N37D, L63P, A71V, Q92QK |
| >CA9531| codons 1-99 PQITLWQRPIVTIKVGGQLMEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |