Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3910 | CA9112 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 72 |
| 2 | AZT+ D4T | 29 |
| 3 | 3TC+ SQV+ AZT | 67 |
| 4 | D4T+ 3TC+ NFV | 32 |
| 5 | RTV+ SQV+ NVP | 63 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W | T215C | Y181C, G190A | E6EK, K20R, V35T, T39A, K43Q, E44D, K102Q, K122E, Q207E, H208Y, R211K, T286P, I293V, P294Q, E297K |
| >CA9112| codons 1-303 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELREYLWKWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKALTEVVQLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L23I | L10I, P39A, L63P, A71V, V77I |
| >CA9686| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLAGRWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLIGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |