Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3885 | CA9077 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+3TC+IDV | 61 |
| 2 | None | 21 |
| 3 | AZT+DDI+NFV | 25 |
| 4 | D4T+DDI+EFV | 13 |
| 5 | D4T+EFV+NFV | 14 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, L210W, T215Y | K103N, Y181YC, G190A | K238T | K43KE, K122E, T165I, E169D, G196E, I202IL, R211K, H221HY, A272P, K277R, I293V, E297A | Q197T |
| >CA9077| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILDPFRKQNPDIVI CQYMDDLYVASDLEIETHRTKLEELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, L19I, E35D, N37D, R41RK, L63P, A71I, I72IV, V77I |
| >CA9661| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEDMDLPGKWKPKMIVGIGGFTKVRQYD QIPIEICGHKIVGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |