<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA3885 CA9077 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+3TC+IDV 61
2 None 21
3 AZT+DDI+NFV 25
4 D4T+DDI+EFV 13
5 D4T+EFV+NFV 14

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67N, L210W, T215Y   K103N, Y181YC, G190A K238T K43KE, K122E, T165I, E169D, G196E, I202IL, R211K, H221HY, A272P, K277R, I293V, E297A Q197T
>CA9077| codons 1-298
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILDPFRKQNPDIVI
CQYMDDLYVASDLEIETHRTKLEELRQHLWKWGFYTPDKKYQKEPPFLWMGYELHPDTWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A   L10I, L19I, E35D, N37D, R41RK, L63P, A71I, I72IV, V77I  
>CA9661| codons 1-99
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEDMDLPGKWKPKMIVGIGGFTKVRQYD
QIPIEICGHKIVGTVLIGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005