<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JIDP25 JIDP25W104 U.S. 1993 HIV1 B PBMC None

Treatment History
Order Regimen Weeks
1 None 52
2 AZT+DDI 160

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Y115F, Q151M V75I, F77L, F116Y, K219E     V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K  
>JIDP25W104| codons 26-238
LTEEKIKALEKMCTEMEKEGKITKIGPENPYNTPVFAIKKKDGTKWRKLIDLRELNKRTQ
DFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGTRYQ
YNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEEL
RQHLLKWGFTTPDEKHQKEPPFLWMGYELHPDK

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    R41K, I62V, H69Y, V77I, I93L C95C*FL
>JIDP25W104| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGYKAIGTVLIGPTPVNIIGRNLLTQLGLTLNF

References
Author Title Citation
Shafer, RW Drug resistance and heterogeneous long-term virologic responses of human immunodeficiency virus type 1 - infected subjects to zidovudine and didanosine combination therapy. J Infect Dis, 1995
Shafer, RW Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations. J Infect Dis, 1994
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005