Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JIDP25 | JIDP25W104 | U.S. | 1993 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | AZT+DDI | 160 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M | V75I, F77L, F116Y, K219E | V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K |
| >JIDP25W104| codons 26-238 LTEEKIKALEKMCTEMEKEGKITKIGPENPYNTPVFAIKKKDGTKWRKLIDLRELNKRTQ DFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGTRYQ YNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEEL RQHLLKWGFTTPDEKHQKEPPFLWMGYELHPDK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, I62V, H69Y, V77I, I93L | C95C*FL |
| >JIDP25W104| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGYKAIGTVLIGPTPVNIIGRNLLTQLGLTLNF |
References
| Author | Title | Citation |
| Shafer, RW | Drug resistance and heterogeneous long-term virologic responses of human immunodeficiency virus type 1 - infected subjects to zidovudine and didanosine combination therapy. | J Infect Dis, 1995 |
| Shafer, RW | Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations. | J Infect Dis, 1994 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |