Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4812 | CA88224 | U.S. | 2007 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 110 |
| 2 | AZT+DDI | 40 |
| 3 | 3TC+AZT | 94 |
| 4 | DLV+NFV+SQV | 116 |
| 5 | APV+D4T+DDI | 17 |
| 6 | D4T+DDI | 14 |
| 7 | 3TC+DDI+IDV+NFV+RTV | 9 |
| 8 | 3TC+APV+DDI+NFV+RTV | 24 |
| 9 | 3TC+EFV+LPV | 161 |
| 10 | 3TC+LPV+TDF | 72 |
| 11 | LPV+TDF | 113 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K219E | Y181C | E6D, K11KR, V35M, T39A, K43E, V111I, D123E, I142V, D177E, I178L, H208Y, R211K, L228H, A272P, K277R, T286A, I293V | E40S |
| >CA88224| codons 1-300 PISPIDTVPVRLKPGMDGPKVKQWPLTEEKIKALMEICASLEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI CQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10V, I13V, N37S, L63P, A71T, V77I |
| >CA88223| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |