<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
1918LE 02CM.1918 Cameroon 2002 HIV1 B PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, V31I, M50L, T112V, I113V, S119P, T124A, T125A, G163T, D167E, V201I, T206S, T218I, L234I, D256E S283G
>02CM.1918| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEALHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGPN
FTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIITQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, L19I, K20I, E35D, M36I, R41K, Q61E, L63V, I64L, C67S, H69K, V82I, L89I  
>02CM.1918| codons 1-99
PQITLWQRPLVTVKIGGQIIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
EIVLEISGKKAIGTVLVGPTPINIIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39N, E40D, K49R, V60I, T107S, D123E, I135T, S163T, E169G, P170T, K173A, Q174K, D177E, Q207E, R211K, V245K, K275Q, K277R, T286A, E291D, V292I, I293V, E297V, E312N, D324E, I329V, Q334D, F346Y, R356K, M357G, R358G, G359S, T369A, E370A, S379G, T386I, K390R, A400T, E404D, V435I, K454R, D471E, Q480H, L491S, L517I, S519N, A534S, A554N  
>02CM.1918| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNDMEKEGKISRIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVSVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSTMTKILGTFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVRQLCKLLRGAKALTDIVPLTVEAE
LELAENREILKNPVHGVYYDPSKELIAEVQKQGDGQWTYQIYQEPYKNLKTGKYAKGGSA
HTNDVKQLAAAVQKIATEGIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGRAGYVTDRGRQKVVSLTETTNQKTELH
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEIVNQIIEQLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Kijak, GH Development and application of a high-throughput HIV type 1 genotyping assay to identify CRF02_AG in West/West Central Africa. ARHR, 2004