<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
1278NG 01CM.1278 Cameroon 2001 HIV1 G PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S24A, V31I, V37I, S39N, I72V, L101I, T112M, T124A, T125A, G134D, K136Q, V201I, T206S, L234I, D270H S283G
>01CM.1278| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMAADFNLPPIVAKEIIANCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKMIHTDNGSN
FTSAAVKAACWWADIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRHYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, I15V, M36L, N37S, L63P, H69Q, L89M  
>01CM.1278| codons 1-99
PQITLWQRPIVTVKVGGQLKEALLDTGADDTVLEELSLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGQKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  T215S     K20R, V21I, V35T, T39A, V60I, D121Y, K122E, I135T, S162N, D177E, T200A, Q207A, R211K, I244V, V245K, A272S, K281R, E291D, V292I, I293V, E297T, G335D, R356K, G359S, K366R, G384E, T386I, A400T, E404D, E415K, P421H, K431T, E449D, V466I, D471E, H483Y, L491S, A502V, Q509K, L517I, S519N, Q520H, Q524E, E529D, A534S  
>01CM.1278| codons 1-560
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFSTPDKKHQKEPPFLWMGYELHPDKWT
VQPVKLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCRLLRGTKALTDIVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVRQLTEAVQKIATESIVIWEKIPKFKLPIQKETWETWWTDYWQATWIPEWKFVNTP
HLVKLWYQLETEPIVGAETFYVDGAANRDTKLGKAGYVTDRGRQKIVSLTETTNQKTELQ
AIYLALQDSGSEVNIVTDSQYVLGIIQAKPDKSESEIVNHIIEELIKKDKVYLSWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Kijak, GH Development and application of a high-throughput HIV type 1 genotyping assay to identify CRF02_AG in West/West Central Africa. ARHR, 2004