<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MP1411 99CM.1411 Cameroon 1999 HIV1 A PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, K14R, G16E, M36I, R41K, H69K, I72V, L89M  
>99CM.1411| codons 1-99
PQITLWQRPVVTVRIEGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAVGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6S, V8I, V35T, T39N, I50V, K122E, D123S, A158S, K173A, D177E, G196E, T200A, Q207A, R211S, V245Q, E248D, A272P, T286A, E291D, I293V, E297R, A304E, E312D, I326V, G335D, Y342F, M357K, R358K, G359S, K366R, A371V, I375V, A376AT, T377L, K390R, E432D, V435A, N447S, R448K, E449D, L452Q, S468I, T470N, D471E, Q480H, H483Y, L491S, Q509T, K512R, L517I, S519N, Q524E, K527R, K530R, V531I, A534S, A554Q  
>99CM.1411| codons 1-560
PISPISTIPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKVGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLEIEQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVPLTREAE
LELEENREILKDPVHGVYYDPSKDLVAEIQKQGQDQWTYQIFQEPFKNLKTGKYARKKSA
HTNDVRQLTEVVQKVTLESIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIAGAETFYVDGAASKDTKQGKAGYVTDRGRQKVVILNETTNQKTELH
AIYLALQDSGSEVNIVTDSQYALGIIQATPDRSESEIVNQIIEELIRKERIYLSWVPAHK
GIGGNEQVDKLVSQGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  T97A V31I, L63M, I72V, L74I, T112V, I113L, T124N, T125A, V126M, G134N, K136Q, D167E, V201I, I203M, T218S, L234I L158LF
>99CM.1411| codons 1-249
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQMDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQEAAYFLLKLAGRWPVKVLHTDNGSN
FTSNAMKAACWWANIQQEFGIPYNPQSQGVVESMNKEFKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQISKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAV

References
Author Title Citation
Njai, HF The predominance of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness. Retrovirology, 2006