<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MP640 97CM.640 Cameroon 1997 HIV1 A PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  L74LM K14R, S24N, K34R, I72V, L101I, G106A, T112I, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, T218S, Q221H, N222K, L234I  
>97CM.640| codons 1-249
FLDGIDKAQEEHERYHSNWRAMANDFNLPPVVAREIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVIMVAVHVASGYIEAEVIPAETGQETAYFILKLAARWPVKIVHTDNGSN
FTSAAVKAACWWADIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQISKIHKFRVYYRDSRDPIWKGPAK
LLWKGEGAV

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, E35D, M36I, R41K, R57K, H69K, L89M  
>97CM.640| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, K122E, D123N, K166R, K173S, D177E, V179I, T200A, Q207A, R211S, V245Q, E248D, K277R, L283I, I293V, P294T, E312D, G335D, M357K, R358K, G359S, K366R, T369A, A371V, I375V, A376V, T377M, E399D, A400T, T403M, E404D, E432D, T470N, D471E, Q480H, H483L, L491S, S519N, Q524K, K527G, E529D, V531I, A534S, A554S  
>97CM.640| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRSQNPEIII
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGTKALTEVVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKKSA
HTNDVRQLAEVVQKVVMESIVIWGKTPKFKLPIQKETWDTWWMDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLNETTNQKTELH
AILLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEKLIGKDKIYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Njai, HF The predominance of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness. Retrovirology, 2006