<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MP1371 99CM.1371 Cameroon 1999 HIV1 CRF02_AG PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, K14R, L28I, V32I, M50I, L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I  
>99CM.1371| codons 1-248
FLDGIDKAQEDHERYHSNWRAMASDFNIPPVIAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIIIVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWADVTQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, I15L, K20I, E34A, M36I, N37S, R41K, H69K, V77I, L89M  
>99CM.1371| codons 1-99
PQITLWQRPVVTVKLGGQLIEALLDTGADDTVLAEISLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLIGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36D, E40D, V60I, K103Q, K104R, D121H, K122E, I135R, I142T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, K275R, K281R, T286A, E291D, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357R, G359S, T369V, A371V, I375V, A376V, K390R, A400T, E432D, V435I, D471E, K476R, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527E, E529D, A534S, A554N, K558R, V559I  
>99CM.1371| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTDICTDMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKQRSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSRNNETPGTRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKQLCRLLRGAKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRSA
HTNDVKQLVEVVQKVVTESIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQRTELH
AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIEKDKVYLSWVPAHK
GIGGNEQVDKLVSNGIRRIL

References
Author Title Citation
Njai, HF The predominance of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness. Retrovirology, 2006