Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MP578 | 97CM.578 | Cameroon | 1997 | HIV1 | CRF02_AG | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13AV, K14R, K20I, M36I, R41K, K43R, H69K, L89M |
| >97CM.578| codons 1-99 PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36D, K49R, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211RK, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357R, R358K, G359S, A371V, I375V, I382T, K390R, T403L, E413D, V435A, V466A, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527E, E529D, A534S, A554NS, V559VI |
| >97CM.578| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTDICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRKSA HTNDVKQLTEVVQKVATESIVTWGKTPKFRLPIQKETWEAWWLEYWQATWIPDWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKAVSLTETTNQKTELH AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIEKDKVYLSWVPAHK GIGGNEQVDKLVSSGIRKIL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| L74M | K14R, V31VI, L63I, L101I, T112V, T124A, G134N, I135V, K136T, V201I, T206S, L234I |
| >97CM.578| codons 1-249 FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQIDCTHLEGKIIMVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN FTSATVKAACWWANVTQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAV |
References
| Author | Title | Citation |
| Njai, HF | The predominance of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness. | Retrovirology, 2006 |