Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MP1378 | 99CM.1378 | Cameroon | 1999 | HIV1 | CRF02_AG | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| Q148K | K14R, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, A169AV, V201I, T206S, Y227F, L234I |
| >99CM.1378| codons 1-249 FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWANVTQEFGIPYNPQSKGVVESMNKELKKIIGQVRDQVEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYFRDSRDPIWKGPAK LLWKGEGAV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K20I, M36I, L38I, R41K, H69K, L89M |
| >99CM.1378| codons 1-99 PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEEINIPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K32KQ, V35T, E36D, K122E, D123S, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375V, V381I, K390R, T403L, K431T, V435A, L452I, D471E, Q480H, L491S, E492Q, K512R, E514D, L517I, S519N, Q524K, K527E, E529D, V531I, A534S, A554S, V559I |
| >99CM.1378| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALTDICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTEVVQKVATESIIIWGKTPKFRLPIQKETWEAWWLEYWQATWIPEWEFVNTP PLVKLWYQLETEPIAGAETFYVDGAANRETKIGKAGYVTDRGRQKVVSLTETTNQKTELH AIHLALQDSGSQVNIVTDSQYALGIIQAQPDRSDSEIVNQIIEKLIEKDKIYLSWVPAHK GIGGNEQVDKLVSSGIRKIL |
References
| Author | Title | Citation |
| Njai, HF | The predominance of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness. | Retrovirology, 2006 |