<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
MP1378 99CM.1378 Cameroon 1999 HIV1 CRF02_AG PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
Q148K   K14R, V31I, I72V, L74I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, A169AV, V201I, T206S, Y227F, L234I  
>99CM.1378| codons 1-249
FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVIIVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANVTQEFGIPYNPQSKGVVESMNKELKKIIGQVRDQVEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYFRDSRDPIWKGPAK
LLWKGEGAV

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K20I, M36I, L38I, R41K, H69K, L89M  
>99CM.1378| codons 1-99
PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEEINIPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K32KQ, V35T, E36D, K122E, D123S, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375V, V381I, K390R, T403L, K431T, V435A, L452I, D471E, Q480H, L491S, E492Q, K512R, E514D, L517I, S519N, Q524K, K527E, E529D, V531I, A534S, A554S, V559I  
>99CM.1378| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALTDICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPAKDLVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLTEVVQKVATESIIIWGKTPKFRLPIQKETWEAWWLEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIAGAETFYVDGAANRETKIGKAGYVTDRGRQKVVSLTETTNQKTELH
AIHLALQDSGSQVNIVTDSQYALGIIQAQPDRSDSEIVNQIIEKLIEKDKIYLSWVPAHK
GIGGNEQVDKLVSSGIRKIL

References
Author Title Citation
Njai, HF The predominance of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness. Retrovirology, 2006