Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AF104 | 05AF104 | Afghanistan | 2005 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, L19Q, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89M |
| >05AF104| codons 1-99 PQITLWQRPLVTVKIGGQQREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6D, V35T, V60I, D121Y, K122E, D177E, V179I, T200I, Q207A, R211K, D250E, A272P, I274V, T286A, E291D, V292I, I293V, E297A, I309L, G335D, R356K, M357K, G359S, E370D, A371V, I375V, A376S, T377M, K390R, T403M, E404D, E432D, V435I, D471E, Q480H, L491S, K512N, L517V, S519N, Q524E, I526V, E529D, A534S, A554N, V559I | K11G |
| >05AF104| codons 1-560 PISPIDTVPVGLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYMDDLYVGSDLEIGQHRIKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGVKVKQLCKLLRGAKALTDIVPLTAEAE LELAENRELLKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTDVVQKVSMESIVIWGKTPKFRLPIQKETWEAWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH AIHLALQDSGSEVNIVTDSQYALGIIQAQPDNSESEVVNQIIEELVKKDKVYLSWVPAHK GIGGNEQVDKLVSNGIRKIL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D6E, K14R, V31I, S39N, I60M, I72V, T112I, I113V, T124A, T125A, V126F, K136H, D167E, V201I, I203M | S283G |
| >05AF104| codons 1-288 FLDGIEKAQEEHERYHSNWRAMASDFNLPPIVAKEIVANCDKCQLKGEAMHGQVDCSPGM WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKIVHTDNGSN FTSAAFKAACWWAGIHQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
References
| Author | Title | Citation |
| Sanders-Buell, E | A nascent HIV type 1 epidemic among injecting drug users in Kabul, Afghanistan is dominated by complex AD recombinant strain, CRF35_AD. | ARHR, 2007 |