Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| pt01 | Pop11-2005 | U.K. | 2005 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | NA |
| 2 | 3TC+AZT+NVP | NA |
| 3 | D4T+DDI+NVP | NA |
| 4 | LPV+SQV+TDF | NA |
| 5 | LPV+TDF | NA |
| 6 | ATV+LPV | NA |
| 7 | FTC+TDF | 86 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, Q18QK, K20I, M36I, R41K, C67E, H69K, V82I, L89M |
| >Pop11-2005| codons 1-99 PQITLWQRPLVTVRIGGKLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEIEGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70G, M184V | V35T, V60I, K122E, I135V, I142V, S162C, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, D250E, S251N, A272P, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329IV |
| >Pop11-2005| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKENWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPAKELIAEVQKQG |
References
| Author | Title | Citation |
| Bradshaw, D | Characterization of a novel drug-resistance pattern associated with the mutations K70G and M184V in HIV-1 reverse transcriptase. | AAC, 2007 |