Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 1604 | 1604_5370 | Botswana | 2005 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+NNRTI | 72 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215FY | K103N, V106M | V35I, T39E, S48T, K102KR, K122E, D123G, I135T, K173A, Q174K, D177E, Q197H, K201R, I202V, Q207A, R211Q, V245Q, A272P, T286A, E291D, I293V |
| >1604_5370| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEEMEKEGKITKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSMTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGHHRTRVEELRAHLLQWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, M36I, D60E, H69K, L89M, I93L |
| >1604_5370| codons 1-99 PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYE QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Novitsky, V | The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in Southern Africa. | ARHR, 2007 |