Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 1282 | 1282_0525 | Botswana | 2005 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+NNRTI | 108 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, R41K, K43R, Q61E, L63P, H69K, T74TA, L89M, I93L |
| >1282_0525| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD EIPIEICGKKAIGAVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39E, S48T, K104KR, K122E, K173A, D177E, Q197K, T200A, Q207N, R211K, V245Q, P247T, D250E, A272P, K277T, T286A, E291D, V292I, I293V, E297K, I329L |
| >1282_0525| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGKHRAKIEELRNHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLTEKESWTVNDIQKLVGKLNWASQIYPGIKVTQLCKLLRGAKALTDIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQG |
References
| Author | Title | Citation |
| Novitsky, V | The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in Southern Africa. | ARHR, 2007 |