Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 1195 | 1195_1995 | Botswana | 2004 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+NNRTI | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K101KE, G190A | K20KR, E28EK, K32KE, V35T, E36A, T39E, D86DN, K122E, D123DN, K173A, Q174K, D177E, T200A, I202IV, Q207E, R211K, D237DN, V245EQ, D250E, A272P, K277R, E291D, V292I, I293V |
| >1195_1995| codons 1-334 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALTAICEEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQNFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYVASDLEIGQHRAKVEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPNKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, N37S, R41K, L63P, H69K, V77I, L89M, I93L |
| >1195_1995| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLIGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Novitsky, V | The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in Southern Africa. | ARHR, 2007 |