<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
1025 1025_0773 Botswana 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI+NNRTI 32

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, M36L, N37S, R41K, L63P, I64IM, H69K, L89I, I93L  
>1025_0773| codons 1-99
PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEELSLPGKWKPKMIGGIGGFIKVRQYD
QIPMEICGKKAIGTVLVGPTPVNIIGRNILTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67DN   V106VA, Y181YC F227FL V35T, E36A, T39E, S48T, K122E, D123S, K166R, K173A, D177E, E194D, T200A, Q207A, R211K, V245Q, E248D, D250E, A272P, K277R, Q278QH, T286A, E291D, V292I, R307RK, Q334QE  
>1025_0773| codons 1-334
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPEIVI
CQYMDDLYVGSDLDIGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTDIIPLTEEAE
LELAENKEILKEPVHGVYYDPSKDLIAEIQKQGE

References
Author Title Citation
Novitsky, V The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa. ARHR, 2007