Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 1025 | 1025_0773 | Botswana | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+NNRTI | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36L, N37S, R41K, L63P, I64IM, H69K, L89I, I93L |
| >1025_0773| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEELSLPGKWKPKMIGGIGGFIKVRQYD QIPMEICGKKAIGTVLVGPTPVNIIGRNILTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN | V106VA, Y181YC | F227FL | V35T, E36A, T39E, S48T, K122E, D123S, K166R, K173A, D177E, E194D, T200A, Q207A, R211K, V245Q, E248D, D250E, A272P, K277R, Q278QH, T286A, E291D, V292I, R307RK, Q334QE |
| >1025_0773| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPEIVI CQYMDDLYVGSDLDIGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPLLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTDIIPLTEEAE LELAENKEILKEPVHGVYYDPSKDLIAEIQKQGE |
References
| Author | Title | Citation |
| Novitsky, V | The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in Southern Africa. | ARHR, 2007 |