Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 0898 | 0898_7976 | Botswana | 2004 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+NNRTI | 82 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, N37S, R41K, I62V, L63A, H69K, A71T, V77I, I93L |
| >0898_7976| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QVAIEICGKKTIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K103N, Y181C | A98G | V35T, E36A, T39E, S48E, K49R, K122E, D123S, K173T, D177E, T200A, Q207N, R211K, D218E, V245Q, K277R, E291D, V292I, I293V, I329L |
| >0898_7976| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKIERIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELRNHLLKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQG |
References
| Author | Title | Citation |
| Novitsky, V | The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in Southern Africa. | ARHR, 2007 |