Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PS2008 | 2008_d377 | Australia | 2005 | HIV1 | B | PBMC | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, L28I, P30A, S39C, M50I, L101I, T124A, V201I, T206S, T218S, D253E, M275V |
| >2008_d377| codons 1-288 FLDGIDKAQEEHERYHSNWRAMASDFNIPAVVAKEIVACCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN FTSATVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQISKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQENSDIKVVPRRKAKIIRDYGKQVAGDDCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13IV, K14R, I15V, E35EK, N37D, D60E, L63T, C67Y |
| >2008_d377| codons 1-99 PQITLWQRPIVTVRVGGQLKEALLDTGADDTVLEKMDLPGRWKPKMIGGIGGFIKVRQYE QITIEIYGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V60I, S68G, D123E, I135T, R211K, A272P, T286A, Q334H, A360V, T369A, K374R, I375V, K390R, A400T, T403V, E404D, Q480H, L491S, S519N, K527N, V531I |
| >2008_d377| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGV HTNDVKQLAEAVQRVATESIVIWGKTPKFRLPIQKETWETWWVDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELH AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKEKIYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Li, B | Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution. | J Virol, 2007 |