Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| pWCML249 | pWCML249 | Kenya | 1997 | HIV1 | D | PBMC | BC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19I, R41K, L63P |
| >pWCML249| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| P4H, V35T, E40D, K49R, V60I, D121Y, K122E, T139A, A158S, D177E, I178L, T200I, Q207G, R211K, V245E, D250E, A272P, K277R, L282C, L283I, T286A, A288T, I293V, L310P, P321Q, E328D, G335D, P345Q, F346Y, A355T, R356K, M357L, A360T, E370A, T377Q, S379C, K390R, A400T, H483N, A534S, A554N, I556V, V559I |
| >pWCML249| codons 1-560 PISHIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTDMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNEAPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPELVI YQYMDDLYVGSDLEIGQHRIKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCIRGAKTLTEVVPLTEEAE LELAENREIPKEPVHGVYYDQSKDLIADIQKQGQDQWTYQIYQEQYKNLKTGKYTKLRGT HTNDVKQLTAAVQKIAQECIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AINLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSNGVRKIL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, L45I, M50I, I73T, T112V, I113V, T124A, T125A, V201I, T218I, L234I, D256E, A265V |
| >pWCML249| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQIKGEAIHGQVDCSPGI WQLDCTHLEGKITLVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Shi, B | Construction of an infectious HIV type 1 molecular clone from an African patient with a subtype D/C recombinant virus. | ARHR, 2004 |