<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
04BR137 04BR137 Brazil 2004 HIV1 C PBMC None

Treatment History
Order Regimen Weeks
1 PI + RTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, N37K, R41N, H69K, L89I, I93L  
>04BR137| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMKLPGNWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNILTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39D, K122E, D123N, I135T, R211K, V245Q, A272S, T286A, E291D, V292I, I293V, V317A, I329L, G335D, R356K, G359T, K366R, T377L, T386V, K390R, E404D, V435A, L452M, V466I, D471E, H483Q, L491S, S519N, K527R, K530R, A534S, A554N  
>04BR137| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLTEAVQKIALESIVIWGKVPKFRLPIQKETWEAWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKMGKAGYVTDRGRQKIVSLTETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIRKERVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, D25E, K34R, M50T, A91T, L101I, T112V, S119P, T122I, T124N, K136Q, V201I, L234I, I251L, D278A V281M, S283G
>04BR137| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMASEFNLPPVVAREIVASCDKCQLKGEATHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPTETGQETAYFILKLAGRWPVKVIHTDNGPN
FISNTVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVLQDNSDIKVVPRRKAKIIRDYGKQMAGADCMAGRQDED

References
Author Title Citation
Sanabani, S Full-length genome analysis of human immunodeficiency virus type 1 subtype C in Brazil. ARHR, 2006