<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CH12 CH12 Chile 2001 HIV1 CRF44_BF PBMC None

Treatment History
Order Regimen Weeks
1 RTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, T12Q, I15V, E35D, M36I, N37E, R41K, R57K, D60E, Q61D  
>CH12| codons 1-99
PQITLWQRPVVQIKVGGQLKEALLDTGADDTVLEDIELPGKWKPKMIGGIGGFIKVKQYE
DILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        D123E, F171FL, R172RK, E194EK, I195IR, R199RK, R211K, F214L, A272P, E291A, I293V, E297R, L301I, K311R, A376T, K390R, Q394L, E399D, A400T, K431T, V435A, A446S, L452Q, S468P, D471E, K476KR, T477A, Q480H, H483Q, L491S, E492EK, T497TP, E516G, S519N, I526IM, K527E, K528KR, K530KR, A534S, V548I I159IL, I482IF, Q500QH, V552VA
>CH12| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPALFQSSMTKILEPLKKQNPDIVI
YQYMDDLYVGSDLKRGQHKTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTAVVPLTREAE
IELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPILKETWDTWWTEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIAGAETFYVDGASNRETKQGKAGYVTDRGRQKVVPLTETTNQRAELH
AFQLALQDSGSKVNIVPDSHYALGIIQAQPDKSESGLVNQIIEQLMERERVYLSWVPAHK
GIGGNEQIDKLASAGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
R263RK T66TP, G163R E11D, V31I, V32I, V37I, M50I, I72V, I84L, P90S, L101I, S119P, T124A, T125A, G134D, K136Q, V201I, K211R, T218I, I220IF, R224RW, L234V, K240R, D256E F100FL, N117NK, W132WG, N254NI
>CH12| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMASDFNLPPIIAKEIIASCDKCQLKGEAIHGQVDCSPGI
WQLDCPHLEGKVILVAVHVASGYLEAEVISAETGQETAYLILKLAGRWPVKTIHTDKGPN
FTSAAVKAACWGADIQQEFGIPYNPQSQGVVESMNKELKKIIRQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQIIKFQNFWVYYRDSRDPVWKGPAR
LLWKGEGAVVIQDISEIKVVPRKKAKIIRDYGKQMAGDDCVASRQDED

References
Author Title Citation
Sierra, M The analysis of near full-length genome sequences of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Chile, Venezuela and Spain reveals their relationship to diverse lineages of recombinant viruses related to CRF12_BF. Infect Genet Evol, 2004