<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KNH1239 KNH1239 Kenya 2000 HIV1 A PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, G16E, E35D, M36I, R41K, L63A, H69K, K70R, L89M, T91V  
>KNH1239| codons 1-99
PQITLWQRPLVTVKIEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIAIEICGKRAIGTVLVGPTPVNIIGRNMLVQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, K49R, K102R, D121H, K122E, D123E, I142V, D177E, Q207E, R211K, V245Q, K281R, E291D, V292I, I293V, E297K, A304E, E312N, G335D, R356K, M357K, G359S, A360T, T377M, K390R, K431R, V435A, A446S, V466I, D471E, K476R, Q480H, H483Y, K512R, E514D, S519N, Q524K, K527E, K530R, A534S, A554S  
>KNH1239| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL
HEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKALTDIVPLTKEAE
LELEENREILKNPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRST
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEREPIAGAETFYVDGASNRETKLGKAGYVTDRGRQKIVSLTETTNQRTELH
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDRSDSELVNQIIEKLIEKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S24Q, I72V, T112V, S119P, T122I, T124A, K136Q, K173R, V201I, K211R, E212A, K215R, Q216N, K219Q, L234I S283G
>KNH1239| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMAQDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGPN
FISATVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLRTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTRALQRNITQIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Visawapoka, U Circulating and unique recombinant forms of HIV Type 1 containing subsubtype A2. ARHR, 2006