Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MW-ins14 | jci-14 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | AZT+DDC | 24 |
| 3 | DDI | 20 |
| 4 | D4T+DDC+PI | 130 |
| 5 | 3TC+D4T+NVP | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | G73S | I15V, L19P, K20I, E35G, M36I, I62V, L63P, A71X |
| >jci-14| codons 1-99 PQITLWQRPLVTIKVGGQPIEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKXISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_SG, L74V, M184V, L210W, T215Y | A62V, D67E | L100I, K103N | K43E, K64R, V111I, K122E, I135T, S162Y, R211RK, L228H, V245E, A272P, K277R |
| >jci-14| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FVIRKKESAKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Winters, MA | A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. | J Clin Invest, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |