Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MW-ins13 | jci-13 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | AZT+DDC | 20 |
| 3 | 3TC+AZT | 24 |
| 4 | D4T+DDI | 36 |
| 5 | 3TC+AZT+IDV | 24 |
| 6 | D4T+DDI+NVP+PI | 24 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, K20R, E35D, M36I, N37X, R41X, D60E, I62V, L63P, A71V, I72X |
| >jci-13| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIXLPGXWKPKMIGGIGGFVKVRQYE QVPIEICGHKVXGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SS, K70R, V75M, L210W, T215F | D67E | K43Q, V118VI, K122E, D123E, K166R, G196E, R211K, A272P, K277R, I293V, P294A, E297A |
| >jci-13| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEQEGKISKIGPENPYNTPV FAIKKKESSRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVALTAEAE LE |
References
| Author | Title | Citation |
| Winters, MA | A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. | J Clin Invest, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |