Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA38129 | CA84910 | U.S. | 2007 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NNRTI|NRTI|PI | NA |
| 2 | Unknown | 52 |
| 3 | DRV+FTC+RTV+TDF | 23 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, M184V | F116Y, T215V, K219Q | K101E, Y181C | V179F | E28K, K32E, V35T, V60I, V118I, K122E, D123E, F214L, L228H, T286A, I293V |
| >CA84910| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYYSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIFI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLVTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84IV, L90M | V11I, L33LF, Q58E, G73S, L89V | L10I, T12K, I13V, K20V, E35G, M36I, N37ND, R57K, L63P, I64V, A71IV |
| >CA84909| codons 1-99 PQITLWQRPIIKVKIGGQLVEALLDTGADDTIFEGIDLPGRWKPKIVGGIGGFMKVKEYD QIPVEICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S39C, L101I, S119ST, T124A, T125A, K156N, R187K, V201I, T218I |
| >CA158558| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVACCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGTN FTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNNELKKIIGQVRDQAEHLKTAVQMAV FIHNFKKKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |