Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| J-A | J-A | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | 3TC+AZT+D4T+IDV | 17 |
| 4 | 3TC+AZT+D4T+NFV | 35 |
| 5 | 3TC+D4T+RTV+SQV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, L33IV, F53FL | L10I, M36MV, N37D, P39X, R41X, I62V, L63P, A71V, I72V |
| >J-A| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVVEEIDLXGXWKPKIIGGIGGLVKVRQYD QVPIEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_SS, M184V, T215Y | A62V | K20R, K43N, V118VI, K122KE, S162C, D177E, R211K, L228LH |
| >J-A| codons 1-251 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FVIKKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDS |
References
| Author | Title | Citation |
| Winters, MA | A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. | J Clin Invest, 1998 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |