Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1429 | CA8486 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 74 |
| 2 | AZT+ DDI | 7 |
| 3 | AZT+ DDI+ 3TC | 25 |
| 4 | 3TC+ DDI+ D4T | 33 |
| 5 | D4T+ DDC+ IDV | 13 |
| 6 | 3TC+ AZT+ IDV | 34 |
| 7 | DDI+ NVP+ IDV | 19 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SG, T215Y | A62V | Y181C | I135T, K166R |
| >CA8486| codons 1-248 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10V, I13V, L19I, L63P, G73X |
| >CA8487| codons 1-99 PQITLWQRPVVTVKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKAIXTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Winters, MA | A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. | J Clin Invest, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |