Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MW-ins4 | jci-4-897 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDC | 104 |
| 3 | AZT+DDI | 104 |
| 4 | AZT+DDI+SQV | 52 |
| 5 | AZT+DDI+IDV | 52 |
| 6 | 3TC+D4T+NVP | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10F | T12N, L19T, K20I, E35D, M36I, N37D, R57K, I62V, L63P, A71V, Q92R |
| >jci-4-897| codons 1-99 PQITLWQRPFVNIKIGGQTIEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKVIGTVLVGPTPVNVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SG, T215Y | D67E | E6ED, V35E, T39A, W88C, K122E, I135T, I142T, S162A, Q207E |
| >jci-4-897| codons 1-253 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALEEICAELEKEGKISKIGPENPYNTPV FAIKKKESSKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWT |
References
| Author | Title | Citation |
| Winters, MA | A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors. | J Clin Invest, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |