Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2084 | CA8472 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 261 |
| 2 | AZT+ 3TC | 41 |
| 3 | D4T+ 3TC+ IDV | 48 |
| 4 | DDC+ 3TC+ NFV | 28 |
| 5 | DDI+ 3TC+ NFV | 29 |
| 6 | ABC+ EFV+ SQV | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | L10F, Q58E | I13V, K14R, K20I, N37D, L63Q, I64V, I72V, I93L |
| >CA8472| codons 10-99 FVTVRIGGQLIEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVREYDQIQVEICGH KAVGTVLVGPTPVNIIGRSLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V | K219Q | K20R, T39N, V60I, T69N, K70X, D123E, I135T, D177E, D218E, A272P, T286A |
| >CA8471| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICNEMEKEGKISKIGPENPYNTPI FAIKKKNSNXWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |