Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2075 | CA8448 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 75 |
| 2 | DDI | 45 |
| 3 | DDC | 40 |
| 4 | 3TC+AZT+IDV | 79 |
| 5 | 3TC+DDC+NFV | 26 |
| 6 | 3TC+RTV+SQV | 2 |
| 7 | D4T+DLV+SQV | 39 |
| 8 | 3TC+AZT+DDI+RTV+SQV | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10I, K20M, E35D, M36I, N37K, R41K, L63P, A71T, I93L |
| >CA8448| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEDIKLPGKWKPKIIGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, T215Y | K219R | Y181C | K20R, K22R, E44D, K49R, E53D, T69N, A98S, V118I, D123E, S162D, K166R, E203K, Q207K, H208Y, L210F, R211E, K223E, L228R |
| >CA8447| codons 1-261 PISPIETVPVKLKPGMDGPRVRQWPLTEEKIKALVEICTELEKDGKISRIGPDNPYNTPV FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIKELRKYLFEWGFYTPDRKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLV |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |