<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2075 CA8448 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 75
2 DDI 45
3 DDC 40
4 3TC+AZT+IDV 79
5 3TC+DDC+NFV 26
6 3TC+RTV+SQV 2
7 D4T+DLV+SQV 39
8 3TC+AZT+DDI+RTV+SQV 9

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M   L10I, K20M, E35D, M36I, N37K, R41K, L63P, A71T, I93L  
>CA8448| codons 1-99
PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEDIKLPGKWKPKIIGGIGGFIKVRQYD
QIPIEICGHKTIGTVLVGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, T215Y K219R Y181C   K20R, K22R, E44D, K49R, E53D, T69N, A98S, V118I, D123E, S162D, K166R, E203K, Q207K, H208Y, L210F, R211E, K223E, L228R  
>CA8447| codons 1-261
PISPIETVPVKLKPGMDGPRVRQWPLTEEKIKALVEICTELEKDGKISRIGPDNPYNTPV
FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIKELRKYLFEWGFYTPDRKHQEEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLV

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005