Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2321 | CA8420 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 25 |
| 2 | 3TC+AZT+IDV | 34 |
| 3 | 3TC+D4T+SQV | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I84IV, L90M | L10I, T12S, K14KR, L19I, E35ED, R41K, I62V, L63LP, I64V, A71V, I93L |
| >CA8420| codons 1-99 PQITLWQRPIVSIRIGGQIKEALLDTGADDTVLEDMNLPGKWKPKMIVGIGGFIKVRQYD QVPVEICGHKVIGTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | A62V | V179D | V35T, K103R, I135T, Q174E, R211K, T215X, K259KR, A272S | N265NT |
| >CA8419| codons 1-277 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIDI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFXTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQRLVGKLTWASQIYSGIKVK |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |