Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6792 | CA84179 | U.S. | 2007 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 104 |
| 2 | 3TC+D4T+IDV | 57 |
| 3 | D4T+EFV+RTV+SQV | 30 |
| 4 | 3TC+D4T+NFV+NVP | 52 |
| 5 | ABC+D4T+DLV+SQV | 148 |
| 6 | ABC+DDI+FTC+LPV | 148 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47IV, I54V, V82A, L90M | F53L | I15V, K20R, M36I, L63P, A71I, I93L |
| >CA84179| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTILEEINLPGRWKPKIVGGIGGLVKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K103N | T39A, T69TA, V90VI, V118I, K122E, I135V, I142V, R211K, V261VG, A272S, K277R, Q278E, I293V, E297K | Y232H |
| >CA84180| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSAKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGHELHPDKWT VQPIVLPEKDSWTVNDIQKLGGKLNWASQIYSGIKVRELCKLLRGTKALTEVVPLTKEAE LE |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| T125A, K156N |
| >CA124200| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FTSTAVKAACWWAGIKQEFGIPYNPQSQGVVESMNNELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |