Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA798 | CA84123 | U.S. | 2007 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 291 |
| 2 | AZT+DDC+SQV | 26 |
| 3 | None | 65 |
| 4 | 3TC+AZT+IDV | 105 |
| 5 | ADV+DDI+EFV | 29 |
| 6 | DDI+EFV | 3 |
| 7 | None | 17 |
| 8 | ABC+ADV+IDV+RTV | 10 |
| 9 | 3TC+ADV+D4T+IDV+RTV | 5 |
| 10 | 3TC+D4T+IDV+RTV | 8 |
| 11 | None | 28 |
| 12 | D4T+DDI+LPV | 42 |
| 13 | None | 13 |
| 14 | 3TC+DDI+RTV+SQV | 26 |
| 15 | None | 15 |
| 16 | DDI+LPV+TDF | 94 |
| 17 | 3TC+LPV+TDF | 185 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | Q58E, G73C | T4A, L10I, I13V, I15V, K20I, E35DN, M36I, R57K, D60E, Q61N, I62V, L63P, I72T, T74S, Q92K |
| >CA84123| codons 1-99 PQIALWQRPIVTVKVGGQLIEALLDTGADDTVLENINLPGRWKPKIIGGIGGFVKVKEYE NVPIEICGHKATCSVLVGPTPFNIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K20R, V35M, K43E, K82R, V118I, K122E, D177E, G196E, E203D, H208Y, R211K, A272P, T286A, I293V |
| >CA84124| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIDELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |