Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2314 | CA8404 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 30 |
| 2 | AZT+DDI | 52 |
| 3 | AZT+D4T | 8 |
| 4 | 3TC+RTV | 26 |
| 5 | 3TC+IDV+RTV+SQV | 30 |
| 6 | 3TC+D4T+NFV+NVP | 69 |
| 7 | 3TC+DDI+SQV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, Q58E | L10LI, I13V, K14R, E35D, M36IL, N37DE, R57K, I62V, L63P, T74TS |
| >CA8404| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVFEDIDLPGRWKPKMIGGIGGFVKVKEYD QVPIEICGHKAIGSVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N, Y181C | V108I, F227L | K20R, K43N, K101R, V118I, I135T, I202IV, E203K, R211K, K223E |
| >CA8403| codons 1-231 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLRKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKVKELRQHLWKWGFYTPDNKHQEEPPLLWMG |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |