<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2314 CA8403 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 30
2 AZT+DDI 52
3 AZT+D4T 8
4 3TC+RTV 26
5 3TC+IDV+RTV+SQV 30
6 3TC+D4T+NFV+NVP 69
7 3TC+DDI+SQV 23

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N K103N, Y181C V108I, F227L K20R, K43N, K101R, V118I, I135T, I202IV, E203K, R211K, K223E  
>CA8403| codons 1-231
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLRKNKSVTILDVGDAYFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKVKELRQHLWKWGFYTPDNKHQEEPPLLWMG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L33F, Q58E L10LI, I13V, K14R, E35D, M36IL, N37DE, R57K, I62V, L63P, T74TS  
>CA8404| codons 1-99
PQITLWQRPIVTVRIGGQLKEALLDTGADDTVFEDIDLPGRWKPKMIGGIGGFVKVKEYD
QVPIEICGHKAIGSVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009