Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1408 | CA8382 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 7 |
| 2 | AZT | 77 |
| 3 | DDC+ D4T | 23 |
| 4 | AZT+ 3TC+ IDV | 46 |
| 5 | AZT+ 3TC+ IDV+ DDC | 7 |
| 6 | D4T+ DDI+ NFV | 29 |
| 7 | 3TC+ DDI+ NFV | 28 |
| 8 | DDI+ NFV+ 3TC | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70E, Q151M, M184V | F116Y | K20R, I31IL, V60I, I135T, E138ED, T200A, R211K, F214FL | K49K* |
| >CA8382| codons 1-234 PISPIETVPVKLKPGMDGPRVKQWPLTEEKLKALVEICTEMEKEGKIS*IGPENPYNTPI FAIKKKNSTEWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DKDFRKYTAFTIPSTNNDTPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | L10V, I13V, K20KR, E35D, N37D, I62V, L63P, I64V, A71T, I72V, V77I, I93L |
| >CA8383| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD QVPVEICGHKTVGTVLIGPTPVNIIGRSLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |