Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1626 | CA8198 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 91 |
| 2 | DDI | 17 |
| 3 | AZT | 21 |
| 4 | 3TC+AZT | 30 |
| 5 | 3TC+AZT+SQV | 30 |
| 6 | 3TC+AZT+IDV | 105 |
| 7 | 3TC+AZT+IDV | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | K20R, V35T, V60I, V106I, D123E, I135IV, S162C, K166R, I178L, Q197E, F214L, D218E, A272P, K277R | W24WC |
| >CA8198| codons 1-287 PISPIETVPVKLKPGMDGPRVKQCPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRKQNPDLVI YQYVDDLYVGSDLEIGEHRTKIEELRQHLLRWGLTTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84IV | L10I, N37X, K55KR, L63T, H69Q, A71AV |
| >CA8199| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMXLPGRWKPKMIGGIGGFIRVRQYD QITIEICGQKVIGTVLVGPTPVNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |