Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1481 | CA8159 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 10 |
| 2 | 3TC+AZT+IDV | 52 |
| 3 | AZT+3TC+NVP+NFV | 7 |
| 4 | 3TC+AZT+NFV+SQV | 17 |
| 5 | 3TC+NFV+SQV | 4 |
| 6 | 3TC+NFV+RTV+SQV | 4 |
| 7 | NFV+RTV+SQV | 4 |
| 8 | NFV+SQV | 21 |
| 9 | 3TC+ABC+DDI+EFV | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | K20I, E35D, M36I, I62V, L63P, G73X |
| >CA8159| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKAIXTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219E | K103N, Y181C | V108I, P225PH | K122E, I135IT, I142V, L228R |
| >CA8158| codons 1-264 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDEKHQKEHPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |