Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2248 | CA8151 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 30 |
| 3 | 3TC+ D4T | 39 |
| 4 | IDV+ AZT+ 3TC | 52 |
| 5 | NFV+ DDI+ D4T | 45 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K20R, V35L, T39A, E44D, A98S, V118I, K122E, I135T, T200A, H208Y, I257L, Q278QH | T253TS, K259K*, N265NT |
| >CA8151| codons 1-283 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQYLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWSVNDLQ*LVGKLTWASQIYAGIKVKHLCKLL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | L10I, K20M, M36V, D60E, Q61E, L63P, I64V, C67S, V82VI, I93L |
| >CA8152| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTILEEVNLPGRWKPKIVGGIGGFIKVRQYE EIPVEISGHKAIGTVLVGPTPINIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |