Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1145 | CA8047 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ D4T | 39 |
| 2 | IDV+ AZT+ 3TC | 52 |
| 3 | SQV+ RTV+ D4T+ 3TC | 17 |
| 4 | NFV+ NVP+ D4T+ 3TC | 48 |
| 5 | SQV+ NFV+ EFV+ ADV+ DDI | 10 |
| 6 | SQV+ EFV+ ADV+ DDI | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73T | L10I, T12P, I15V, L19I, K20I, L63P, I64V, A71I, P79AS, I93L |
| >CA8047| codons 1-99 PQITLWQRPIVPIKVGGQIIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKIITTVLVGATPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219Q | K101P, K103N | T39A, E40F, K43E, V60I, K122E, D123E, I135T, I178M, V179I, G196E, E203K, Q207D, H208Y, R211K, L228H, A272P, T286A |
| >CA8046| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYVDDLYVGSDLEIEQHRTKIKELRDYLWKWGFYTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Palmer, S | Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development. | AIDS, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |