Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA793 | CA8012 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | DDI | NA |
| 3 | 3TC+AZT+SQV | 69 |
| 4 | 3TC+D4T+SQV | 17 |
| 5 | 3TC+D4T+NFV | 21 |
| 6 | D4T+DDI+NVP+IDV | 79 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | I13V, I15V, E35D, M36L, N37S, R41K, I62V, L63P, A71T, I72IV, I93L |
| >CA8012| codons 1-99 PQITLWQRPLVTVKVGGQLKEALLDTGADDTVLEDLSLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGHKTVGTVLVGPTPVNIIGRSLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N | A98AG | V35M, T39K, K43E, I135M, T200A, E203D, R211K |
| >CA37919| codons 1-249 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICKELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIDELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEK |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |