Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1461 | CA7997 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 30 |
| 2 | DDI+ AZT | 17 |
| 3 | DDC+ AZT | 40 |
| 4 | SQV+ DDC+ AZT | 103 |
| 5 | 3TC+ AZT | 14 |
| 6 | IDV+ D4T+ 3TC | 34 |
| 7 | DDI+ NVP+ D4T | 23 |
| 8 | SQV+ RTV | 60 |
| 9 | NFV+ SQV+ 3TC+ DDI | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L90M | F53L, G73T | L10I, D60E, I62V, L63P, A71I, V77I, I93L |
| >CA7997| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLVKVRQYE QVPIEICGHKIITTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, T69AD, M184V, L210W, T215Y | V75VL | Y181YC | K20R, V21I, T39A, E40FV, K43E, K66KR, K101KQ, V118I, K122E, D177E, I178M, T200A, Q207E, H208Y, R211K |
| >CA7996| codons 1-257 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPV FAIKKRNSAKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYVDDLYVGSDLEIGQHRAKIEELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDI |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |